The First Hughes Ministry was the twelfth Australian Commonwealth ministry, and ran from 27 October 1915 to 14 November 1916.

Australian Labor Party

• Rt Hon Billy Hughes, KC MP: Prime Minister, Attorney-General. Minister for Trade and Customs (from 14 September 1916)
• Senator Hon George Pearce: Minister for Defence
• Hon Frank Tudor, MP: Minister for Trade and Customs (to 14 September 1916)
• Hon Hugh Mahon, MP: Minister for External Affairs
• Hon Jens Jensen, MP: Minister for the Navy
• Hon William Higgs: Treasurer (to 27 October 1916)
• Hon King O'Malley, MP: Minister for Home Affairs
• Hon William Webster, MP: Postmaster-General
• Senator Hon Albert Gardiner: Vice-President of the Executive Council (to 27 October 1916)
• Senator Hon Edward Russell: Assistant Minister (to 27 October 1916)